Quel danger de l'hydroxychloroquine dans les hôpitaux français pendant la crise du COVID ?

L'article de référence, jusqu'à présent, indique

https://www.sciencedirect.com/science/article/pii/S075333222301853X?via%3Dihub
"The median number of HCQ-related deaths in Belgium, Turkey, France, Italy, Spain, and the USA was 240 (range not estimable), 95 (range 92–128), 199 (range not estimable), 1822 (range 1170–2063), 1895 (range 1475–2094) and 12739 (3244− 15570), respectively"

Si l'hydroxychloroquine était définitivement accusé de 200 morts évitables en France, faut-il comprendre que l'hydroxychloroquine était un vrai danger ou qu'en fait ce sont des chiffres anecdotiques à savoir qu'il y a toujours un médicament qui aura de moins bons scores qu'un autre ?

Une étude est proposée sur medRxiv qui me semble, au feeling, important.

https://www.medrxiv.org/content/10.1101/2024.01.18.24301464v1.full-text

"previous findings did not adequately address dose-subgroup and sensitivity analyses which precludes any overall firm conclusions on in-hospital mortality attributable to HCQ"

"Only high dose regimens of HCQ are associated with a significant increase in mortality"

"Applying an excess of mortality in the population treated with doses where no increase of mortality is found creates a misleading overestimation of deaths associated with the use of HCQ in hospitalized patients with COVID-19.

"On the other hand, even at low doses HCQ regimen, no reduction in mortality with HCQ was observed suggesting that, when it comes to mortality as the outcome, HCQ did not show a benefit in hospitalized patients suffering from COVID-19."

Les doutes s'accumulent sur la pertinence de l'étude initiale (Pradelle et al), poussant à ce commentaire du journal :

"After assessing all the information at this stage, and the extent and depth of the criticism, the Editor-in-Chief has made the decision to change approach and handle this matter through the Committee on Publication Ethics (COPE) process for corrections to the scientific record: "

https://www.sciencedirect.com/science/article/pii/S0753332224000647

Les doutes s'accumulent tellement que le Committee on Publication Ethics (COPE) a décidé la rétractation de l'article de Pradelle et al.
https://www.sciencedirect.com/science/article/pii/S075333222301853X